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Biochemistry of Phenotype


Understanding the relationship between an individual’s genotype and phenotype is one of the central challenges in modern biology. Research labs in this area use several approaches to tackle this key goal, including the investigation of biochemical signaling in the genotype-phenotype map, the development of biochemical tools for perturbing systems, and the manipulation of these systems to treat disease.


     •      Norm Arnheim - Molecular & Computational Biology

     •      Matt Dean - Molecular & Computational Biology

     •      Ian Ehrenreich - Molecular & Compuational Biology

     •      Steve Finkel - Molecular & Computational Biology

     •      Scott Fraser - Molecular & Computational Biology

     •      Steve Kay - Molecular & Computational Biology

     •      Peter Kuhn - Molecular & Computational Biology

     •      Sergey Nuzhdin - Molecular & Computational Biology

     •      Nicos Petasis - Chemistry

     •      Fabien Pinaud - Chemistry

     •      Matthew Pratt - Chemistry

     •      Raymond Stevens - Chemistry

     •      John Tower - Molecular & Computational Biology

     •      Clay Wang - Chemistry

Convergent Bioscience, Engineered Systems & Drug Discovery

This research group seeks to develop a deeper understanding of the processes and structures that control human biology. To accmpolish this goal, the associated research labs use several approaches, including the development of synthetic chemistry and small molecules, the creation of synthetic organs and biocompatible materials, and the development of innovative biotechnology tools.


     •      Andrea Armani - Chemistry

     •      Julio Camarero - Pharmaceutical Sciences

     •      Vadim Cherezov - Chemistry

     •      Moh El-Naggar - Chemistry

     •      Valery Folkin - Chemistry

     •      Scott Fraser - Molecular & Computational Biology

     •      Malancha Gupta - Chemistry

     •      Vsevolod Katritch - Molecular & Computational Biology

     •      Steve Kay - Molecular & Computational Biology

     •      Peter Kuhn - Molecular & Computational Biology

     •      Noah Malmstadt - Chemistry

     •      Charles McKenna - Chemistry

     •      Nicos Petasis - Chemistry

     •      Fabien Pinaud - Chemistry

     •      G. K. Surya Prakash - Chemistry

     •      Matthew Pratt - Chemistry

     •      Richard Roberts - Chemistry

     •      Raymond Stevens - Chemistry

     •      Mark Thompson - Chemistry

     •      Chao Zhang - Chemistry

     •      Travis Williams - Chemistry

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DNA Dynamics

Understanding the molecular mechanisms behind DNA replication and genome maintenance is key for understanding life itself. Research labs in this area use chemical synthesis, state-of-the-art biophysical techniques, classical cell biology and molecular genetics to uncover these pathways.



     •      Oscar Aparicio - Molecular & Computational Biology

     •      Steve Bradforth - Chemistry

     •      Xiaojiang Chen - Chemistry

     •      Irene Chiolo - Molecular & Computational Biology

     •      Steve Finkel - Molecular & Computational Biology

     •      Susan Forsburg - Molecular & Computational Biology

     •      Myron Goodman - Chemistry

     •      Charles McKenna - Chemistry

     •      Matthew Michael - Molecular & Computational Biology

     •      G. K. Surya Prakash - Chemistry

     •      Peter Qin - Chemistry

     •      Remo Rohs - Chemistry

     •      Andrew Smith - Molecular & Computational Biology

     •      Arieh Warshel - Chemistry

Molecular Imaging

This research group is driven by the need to assess molecular events in living cells and tissues, and meets this mandate through the development and application of new imaging reagents, protocols, and instruments. Their goal is to permit closed-loop tests of mechanisms proposed from large-scale/high-throughput analyses and modeling studies.


     •      Don Arnold - Molecular & Computational Biology

     •      Andrea Armani - Chemistry

     •      Steve Bradforth - Chemistry

     •      Irene Chiolo - Molecular & Computational Biology

     •      Moh El-Naggar - Chemistry

     •      Valery Folkin - Chemistry

     •      Susan Forsburg - Molecular & Computational Biology

     •      Scott Fraser - Molecular & Computational Biology

     •      Steve Kay - Molecular & Computational Biology

     •      Matthew Michael - Molecular & Computational Biology

     •      Fabien Pinaud - Chemistry

     •      Peter Qin - Chemistry

     •      Susumu Takahashi - Chemistry

     •      Arieh Warshel - Chemistry

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Structural Biology

Our structural biology affinity group seeks to develop a comprehensive understanding of the structure and dynamics of biological systems at a wide range of length and time scales, including atomic details of proteins, nucleic acids and their complexes, to the 3D organization of large molecular machineries to the higher order organization of these macromolecular assemblies in the cell, including the entire genome in the nucleus.


     •      Frank Alber - Molecular & Computational Biology

     •      Oscar Aparicio - Molecular & Computational Biology

     •      Alex Benderski - Chemistry

     •      Lin Chen - Chemistry

     •      Xiaojiang Chen - Chemistry

     •      Vadim Cherezov - Chemistry

     •      Myron Goodman - Chemistry

     •      Anna Krylov - Chemistry

     •      Fabien Pinaud - Chemistry

     •      Richard Roberts - Chemistry

     •      Remo Rohs - Chemistry

     •      Chao Zhang - Chemistry